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today we’re going to talk about the  most common cause of a liver transplant  

and this thing i’m going to talk about is the  number one cause of liver transplant in the u.s  

and the second most common cause of a liver  transplant in the world and that would be  

acetaminophen commonly known as tylenol now if  you’re in europe it may be called paracetamol  

now here’s the problem the active ingredient in  tylenol which is acetaminophen is in quite a few  

over-the-counter medications it’s in alka-seltzer  plus benadryl excedrin it’s in pacoset ribotusin  

pseudofit theraflu vix nyquil and dequel and  in vicodin and many of these medications come  

in one gram tablets but here’s the problem only  four grams a day is an overdose you should never  

take more than three grams in a 24 hour period  because the toxicity from this chemical literally  

destroys the liver cells and this destruction  is irreversible now to make things worse if you  

have a fatty liver if you have cirrhosis if you  have hepatitis if you’re an alcoholic if you’re  

a heavy smoker and if you are on antidepressant  medication or antibiotics or you drink a lot of  

aspartame because you drink a lot of diet sodas  all of this weakens the liver to the point where  

three grams in a 24-hour period is highly toxic if  not deadly so here’s what happens the liver makes  

two enzymes that are supposed to dismantle  this chemical and turn it into a harmless  

byproduct but what happens when you overload  these two enzymes too much with this chemical  

it gets saturated and then the third enzyme  comes in to try to cope with this and then you  

start depleting your glutathione which is a very  important protective antioxidant for the liver  

then you start getting necrosis of  the hepatocyte or the liver cells  

now the term necrosis is the death of body tissue  so your liver cells hepatocytes basically die  

i want to give you a little reality on how  easy it is to overdose on this chemical  

let’s say you’re taking nyquil and alka-seltzer  plus and you’re taking two of each twice a day  

which doesn’t seem to be that outrageous  right well right there that equates to 4 450  

milligrams of acetaminophen which is a toxic dose  so basically by taking just these two medications  

okay two doses twice a day you literally can  cause liver failure all right so what can you do  

if you accidentally take this amount number one  activated charcoal take it within one hour okay  

that will help to minimize the toxicity number  two nac this is a natural remedy a very powerful  

antioxidant for the liver then we have milk  thistle which is a very powerful effective  

herb that can help protect the liver cells as well  and the third option is to get a liver transplant  

the problem is there’s a long waiting list for a  new liver and who knows if you’re going to get one  

so the key is basically having the knowledge  of this data so you can avoid accidentally  

overdosing on tylenol all right thanks for  watching and i will see you in the next video  

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