Video

Transcript

I’d like to talk about the genetic

aspects of Alzheimer’s disease

unfortunately Alzheimer’s has become a

massive problem worldwide and it touches

54 of the population so sooner or later

you are going to run into this topic and

I want to give you some very important

information on prevention as well as

what you can do if you have it yourself

or a friend or family member has this

condition but I want to talk about a

genetic tendency for Alzheimer’s okay if

you get your genes tested which I’m not

necessarily recommending you do or you

don’t I just want to educate you on a

very specific common Gene that shows up

with 20 of the population and this

involves a variation in a gene called

apoe but basically this molecule helps

you transport

uh cholesterol

into the brain now it does a lot of

other things but the area that I’m going

to focus on is what it does in the brain

it transports cholesterol into the brain

okay and helps maintain cholesterol

levels

as well as clear as cholesterol out of

the brain so you can think about apoe is

really a shuttle or a little carrier

boat that transports cholesterol and

there’s three variations that you could

potentially have the first one is apoe

two okay and then you have an apoe tree

and the next one is a poe4 okay now I

guess the best way to help you

understand this simply is that APO E2

would be comparable to ordering

something through Amazon you know

getting it Prime and you get it

overnight so it’s a fast delivery of a

certain product if you have a Poe II

you’re going to be able to transport

cholesterol very very fast and you’re

going to be able to clear it very

quickly as well and about five percent

of the population has this variation

apoe two and they will rarely ever get

Alzheimer’s so now apoe three well that

would be like you know using like FedEx

or UPS

pretty decent delivery not too fast not

too slow probably is going to arrive in

three days maybe a week and so if you

have the variation which 75 percent of

the population has you have a normal

function of that Gene and so you’re not

really at risk of getting Alzheimer’s

but the real problem comes in with the

next

variation called apoe4

if you have this variation in your DNA

this would be equivalent to using the

regular post office during the holidays

it’s going to be extremely slow and you

may have some issues twenty percent of

the population has this

apoe4 fraction and they’re at risk for

getting Alzheimer’s okay especially if

it’s late stage Alzheimer’s and now

you’re probably asking like what does

cholesterol have to do with Alzheimer’s

right well did you realize that your

brain is 25

made up of cholesterol in fact your

brain cells make cholesterol uh this

cholesterol is needed for many many

different things and I’m not just

talking about cholesterol I’m talking

about other types of lipids as well so

your brain it’s like 65 fat and it uses

a lot of cholesterol to make uh its

coating or its myelin sheath it uses

triglycerides for energy it needs

cholesterol for the synapses to work to

allow it to adapt to stress and it needs

it desperately to be able to repair and

what’s very unique about Alzheimer’s is

that if we don’t have enough cholesterol

that’s driven into the neuron okay you

will start losing synapses especially in

certain parts of your brain that involve

memory learning concentration like the

hippocampus and even the frontal cortex

and so really you have a cholesterol

deficiency in your neurons now this is

pretty interesting because we always

think about cholesterol being a really

bad thing but in this case it’s a very

good thing if you have enough

cholesterol but at the same time there’s

some other things going on

because remember I mentioned that this

protein also clears cholesterol from the

brain so we have this situation where we

have a deficiency of cholesterol which

is basically killing off the neurons at

the same time have this toxicity of a

lack of clearing of cholesterol so it’s

called lipotoxicity which comes with a

lot of issues including resultant

plaquing you increase this lip of

toxicity by a factor of 4X now your

brain is now going to do something to

compensate for this so it’s going to

force the brain to switch to glucose

metabolism but the problem is this Gene

also blocks the ability to absorb

glucose too now since glucose is blocked

really what’s happening is we’re getting

a lack of fuel to the neurons the

absolute best thing you can do is start

the ketogenic diet where you lower carbs

you start doing intermittent fasting and

ketones bypass this problem and feed the

neurons directly so basically we have a

situation we have low cholesterol trying

to switch to glucose but can’t and so we

really have a problem with lack of

material to build the membranes as well

as a lack of fuel to feed neurons now

the reason why this is associated with

late stage Alzheimer’s is because just

Aging in general causes you to lose the

ability to utilize the cholesterol too

so it’s kind of like a compounding thing

where this variation cause is a low

cholesterol but then aging makes it

worse and this is why if you have this

Gene problem it could potentially kick

in around 60 to 65 years old or a little

bit later the other really interesting

thing about cholesterol in general is

that when someone takes a lipophilic

Statin their risk of dementia goes way

up why do you think that is well because

statins block cholesterol and when

someone takes a Statin they really have

a problem with certain parts of the

brain that are involved with Alzheimer’s

so in one study they found that if

you’re on a lipophilic Statin your

chances of getting Alzheimer’s doubles

realize this because someone has this

genetic problem there is something you

can do about it because there’s

something called epigenetics which are

those actions that are related to

Lifestyle diet environment that you can

suppress this Gene so it doesn’t become

active it doesn’t become a problem and

things can work correctly the first

thing is to avoid alcohol alcohol is a

very potent effect worsening this

problem and kicking in this Gene so it’s

more expressed and there’s more problems

number two to avoid smoking that has a

huge impact on this Gene as well as well

as secondhand smoking number three

exercise I’m talking about consistent

regular exercise as a significant effect

on this Gene it can greatly greatly help

you you know our bodies are designed to

exercise and move and if we’re not

exercising all sorts of problems occur

but the exercise alone as one factor can

help decrease atrophy of the hippocampus

in your brain which is intimately

involved in memory and concentration and

learning exercise increases blood flow

to the brain directly it also increases

something called the bdnf the brain

derived neurotrophic factor which is

similar to miracle grow for your brain

it helps you grow new brain cells and

exercise is a potent stimulus to

increase this bdnf most of the

population has insulin resistance and

exercise is a great way to improve that

situation and what’s interesting about

that is when someone has plaquing in the

brain because they have Alzheimer’s the

plaquing can

insert into your insulin receptors and

actually cause insulin resistance in the

brain and there’s a huge association

between insulin resistance and dementia

and Alzheimer’s so anything you can do

to improve insulin is a very very good

thing and I’m going to mention just two

things right now going a low carb diet

fasting

taking a natural form of vitamin B1 and

taking apple cider vinegar in your water

those things are very very significant

and lastly exercise can help reduce

inflammation in your brain the next

thing I want to mention is omega-3 fatty

acids that can greatly help you one of

the problems with omega-3 fatty acids

especially if you’re very very deficient

and you have a lot of inflammation it

could take quite some time to replenish

the brain with omega-3 fatty acids

specifically DHA it could take in some

people up to 2.5 years

to fully replenish your stores of

omega-3 fatty acids it doesn’t happen

overnight now there’s another very

fascinating

compound that I want to bring up that

I just recently learned about its

association with helping someone with

dementia and Alzheimer’s and it’s called

Ted cup I talked about tadka in my other

videos but what is a type of bile salt

we have bile that’s made by our liver

that’s stored in the gallbladder that

helps us break down fats also our

friendly bacteria makes a secondary type

of bile but there’s a type of bile which

is a little bit different called tadka

that has many different benefits one

would be to prevent gallstones but it

has a very potent effect on your brain

it’s neural protective you can cross the

blood-brain barrier it can help increase

insulin sensitivity in your brain it can

directly inhibit the plaque formation

that is involved in Alzheimer’s it can

help improve the neurons in the

prefrontal lobe as well as the

hippocampus and it actually has

protective effects in the mitochondria

inside your neurons so tatka is a very

interesting molecule especially as this

relates to the first topic of

cholesterol regulation because what bile

salts do in general for the body is they

help to balance out and regulate and

modulate cholesterol but I had no idea

until recently of what it can do to

cholesterol in the brain because

remember this genetic variation is

creating a big problem with two things

one a deficiency of cholesterol as well

as a lack of clearing of cholesterol in

the brain so

I think tatka is really just helping you

clear out this excess cholesterol that’s

just my theory and I don’t know for sure

the last remedy I’m going to recommend

is vitamin D3 okay now this also relates

to cholesterol because in order to make

vitamin D3 you need cholesterol and this

is why people that take statins end up

with a low vitamin D situation and

vitamin D is intimately involved with so

many different things immune system uh

pain depression but it also has a huge

effect on the brain and these are facts

okay and I’m going to put all the

references down below your cognitive

decline is increased by a factor of 19

fold that’s 19x when you are deficient

in vitamin D dementia is associated with

a vitamin D deficiency your 21 percent

more likely to get alzheimer’s than you

would be if you had normal vitamin D

levels you’re four times less likely to

develop Alzheimer’s if you have high

levels of cholesterol in your blood now

if you haven’t seen my video on tatka

there’s a lot more that it can do check

it out I put it up right here