Video

Transcript

hello everyone so before Dave Feldman

does his talking cholesterol I wanted to

first give you some basic understanding

of the definitions he’s going to use so

you really can digest and understand

everything that he’s going to say okay

so we’re gonna start with this

definition of cholesterol so the first

thing you need to know is that

cholesterol is not really a fat it’s not

a fat it’s a fad like waxy substance

okay so let’s start with the purpose of

cholesterol number one it provides the

raw material to certain hormones okay

number two it makes up all of your

cellular membranes so in other words the

outer shell of your cells are made up of

cholesterol 3 it makes up part of the

brain without cholesterol the brain will

not work correctly also a part of the

nervous system the insulation around the

nerves is made from cholesterol 4 it

helps make bile

so what’s bile bile is the detergent

that helps you break down certain fats

to turn them into fat type of vitamins

essential fats that you need like

omega-3 fatty acids and it helps you

make certain vitamins like vitamin D so

without cholesterol you can’t make bile

and you cannot make vitamin D so it has

a very important purpose everyone’s

focused on cholesterol being bad it’s

gonna clog your arteries but cholesterol

is very very important to actually help

make up part of the body tissues alright

so the next thing you need to know is

that the body makes a lot of cholesterol

itself it makes roughly about 3,000

milligrams of cholesterol every single

day that encompasses 75% of the

cholesterol in your body so if we were

to take you to cluster out of your body

75% of it would be made by your body and

only 25% of it comes from the diet the

next point is that cholesterol is a part

of plaquing as in a clogged artery ok

but it’s not the cause of the plaquing

it’s a part of the crime scene but it’s

not the criminal just because there’s

cholesterol in a plaque doesn’t mean

that it caused the plaque cholesterol is

there as part of a band-aid trying to

heal

something as you’re gonna find out it

has several really important purposes

and let me just touch on this word

triglycerides okay simply it is a type

of fat that makes up your fat cell it

also can be consumed from your diet to

supply energy or be used to store fat

carbohydrates that you eat can be

converted to triglyceride in the fat

cell so triglycerides are called lipids

and what you need to know is that

cholesterol triglycerides and other flip

it’s are hydrophobic which means they

don’t mix well with water okay like oil

and water do not mix so then the body

has to do certain things to make it mix

with water to allow the fat to travel to

the rest of the cells why because it

provides the raw material to hormones

and helps make up the cell membrane help

support the brain makes the bile of

vitamin D how is it going to do that if

it can’t be transported so your body

adds a protein to the lipid and that is

called Lippo proteins okay

let’s go to the next section on that

okay so in this section we’re going to

talk about the five lipoproteins

okay lipoproteins basically our boats or

carriers to transport fat and

cholesterol to the body because fat

doesn’t mix well it’s hydrophobic with

water so we need to add a protein to the

fat to allow it to travel through the

body okay so the first one we’re gonna

talk about is this thing called a Kyllo

micron okay what is that basically that

is a boat that transports the dietary

fat that fat from your diet from the

small intestine to the cells okay so

this is created when you’re eating so

it’s a boat that takes the diet fat and

it brings into the cells

okay another name for this chylomicron

is ultra low density lipoprotein so let

me explain this because it’s a little

confusing

ultra low density because if you look at

the other ones in relationship to this

one you have something called very low

density lipoproteins intermediate

density lipoproteins low-density

lipoproteins and high-density

lipoproteins so if something is more

dense high-density that means it’s more

compacted okay

so you see how small it is now look at a

chylomicron it’s ultra low density so

it’s bigger it’s not very dense it’s an

ultra low density particle okay so then

we have very low density lipoprotein

it’s smaller and it gets smaller and

smaller and smaller and reality we’re

just making something more dense so

that’s just another way to understand

the relationship between all of these to

try to make it a little bit simpler okay

so the chylomicron is created when

you’re eating but when you’re not eating

and you’re fasting okay what we have to

do is we have to take the energy or fat

from the fat cell and transport that to

the cells okay we need a shuttle for

that and the first shuttle is the very

low-density lipoprotein so basically you

have this boat that has this energy that

it’s going to start feeding the cells

okay feeding it fat triglycerides and

then it’s going to end up as a

low-density lipoprotein so you can kind

of look at this is these three together

as a kind of a transition phase so we’re

going to go from here to here to here

and by the way there are other functions

than just feeding the cell as well and

number one it’s going to provide vitamin

E and other antioxidants to actually

neutralize free radicals help neutralize

pathogens there’s even a little bit of

carotenoid in here which is another

antioxidant so the very low-density

lipoprotein carries the fat from the

liver to the cells and then this would

be the next phase with the LDL which

when it’s done with its purpose it gets

recycled by the liver now what is the

HDL the high density lipoprotein do it

carries excessive cholesterol that’s

still lingering around from these guys

back to the liver to be recycled or used

for some other purpose so each of these

boats

their own percentages of triglycerides

cholesterol and protein okay and that’s

what makes them different all right so

now that you have a little background

let’s go right into Dave Feldman’s talk

he’s a senior software engineer business

developer and an entrepreneur in April

of 2015 he began a low-carb high-fat

diet and after experiencing a

significant rise in his total

cholesterol committed himself to

learning everything he could about

cholesterol and the lipid system lipid

his fat right

using his engineering background so here

to make a pretty complicated subject

simple for you are you gonna come up

here and say something

Dave Felton thank you thank you so much

I’m curious do you guys do you guys like

plays yeah yeah I mean you ever go out

to the theater kind of get to enjoy a

night on the town well what I’ve liked

about this conference is fairly early on

when Eric approached me we started

chatting up this idea that would sound

outlandish to other conferences but this

isn’t like other conferences right now

so I would like to introduce to you an

important cast that’s actually at play

right now inside your body please

welcome the cast of the lipid system

[Applause]

we’ll stop yeah just stay here come on I

know I know we really decked it out on

the pricing here now I’m gonna do is

have you guys a little bit more over

here and spread out so that the podiums

not too much in the way hope you guys

have a decent view nabiollah ford here

perfect alright so how many of you guys

had a fatty meal Wow a lot of you a lot

of you had a fatty meal it’s interesting

well what happened to those fatty acids

that were being pulled through your

digestive system well they got packaged

into something called a kite sorry a

triglyceride

now the triglyceride as we see here by

your digestive tract is having trouble

getting it into the bloodstream and

that’s because it’s hydro phobic but she

has about to transport and that is

called the chylomicron a lipoprotein now

the chylomicron is kind of like a waiter

it’s moving around your bloodstream

going to these different cells and oh

one of the cells would like a

triglyceride and now that all of the

triglycerides are off of the chylomicron

it then gets absorbed by the liver

however you’re not always eating right

so at a certain point you are fasting

you hear much about fasting at this

conference your body should be in a

state of fasting not just overnight but

also between meals so then what happens

don’t we still have some cells that need

energy you can tell that’s by the way

the signal that you know the cells need

the energy well fortunately the liver

can help out and it does so using the

fat cells

the liver has its own boat known as a

VLDL and there it is

with fat cells ultimately supplying

those triglycerides through the liver to

the boat and now it does the same thing

that chylomicrons were doing but from

its own boat

go ahead and now that it’s relieved of

all of its triglycerides

unlike the chylomicron it has a second

job it is an LDL particle so now it has

things you hardly ever hear about one of

those for example is that it actually

helps to neutralize pathogens it does so

with something known as vitamin E ooh

was a nice ring but now that it’s

totally out of vitamin E what can it do

with this last pathogen that’s coming

forward well fortunately it can bind to

that pathogen to help clear it

and that ladies and gentlemen is your

lipid system at work as we see it now

thank you so much oh my gosh we were

gonna do a a theater bow here we go

okay get one more big round of applause

for everybody you volunteered for this

thank you guys so much so now if I could

get my presentation up I think we’ll be

ready to get started hopefully this

isn’t double making me all right keto

and cholesterol so it’s kind of a

sentiment that I’ve seen the entire time

I’ve been working in this and it’s will

be actually three years next month but

very early on in the literature

I saw effectively what you see in this

cartoon which if you can’t read it says

we already know the killer is

cholesterol we just need to get enough

evidence to prove it and that’s

effectively what I’ve seen over and over

again and again I’m an engineer like

Iver you can’t say something like hey

we’re at risk for a meteor strike and

it’s incumbent on me to prove you wrong

it’s up to you to actually prove the

meteor strike is in fact imminent that

we should do something about it so let’s

go back before three years ago in my own

health journey this was what I would

call my fighting weight and I don’t know

if any of you guys have ever done this

I’ve done this when I was running and

yet I still somehow had a gut if I knew

I was coming up on a camera while

running I try to suck in my gut I try to

get the shot right well I certainly may

not be able to see my gut in these shots

but you can certainly see my neck in my

face I was definitely a lot puffier this

next picture was actually my engagement

photos with my wife

and at that time I weighed quite a bit

more than I do now well this is me now

start Quito in April 2015 lost 25 pounds

and the big moment again was about three

years ago next month I became obsessed

with cholesterol research since seeing

my total and LDL cholesterol skyrocket

and after that I began extensive in

tawan experiments to learn more and for

those of you in the room who know what I

mean by extensive in of one experiments

you know the inside joke for those of

you don’t let’s have a little journey

together so I take metrics constantly

this is back these are old pictures you

can tell because I have a precision

extra when in fact I like to use keto

mojo all the time now I have it for both

glucose for ketones I do blood pressure

I do like a whole bunch of metrics but

this is probably what I’m most known for

I take a picture of every single thing

that I ingest everything in fact at

every conference I make everyone aware

of this I will give you $100 if you can

capture me

ingesting anything that I didn’t already

take a picture of first but I’m gonna

warn you my wife hasn’t collected on

that so it’s not looking good yes this

is literally everything you may have

noticed my left hand appears in it and

that’s so that there’s always a

reference for volume so if I’m not

actually weighing it I can be sure that

I know approximately what the quantity

is but a lot of times I weigh it as well

like you see I’m doing here with the

shredded cheese and when I say

everything I’m not talking just

foodstuffs I’m talking also supplements

and yes

even water every single sip of water

that I’ve had I even have a symbol by

the way for when I go to a water

fountain and I hold up how many fingers

for how many gulps that I’ve done now

why am I doing this why am i capturing

every single thing I’m eating this

obsessively well they have to match with

my blood tests how many blood tests have

I had I’ve had about a hundred and five

in the last 35 months since my research

has begun and the reason I emphasize

this is because I take the data that I’m

collecting very seriously to the extent

to where when I’m doing these

experiments

I can show you just how tightly

controlled it is that’s what’s going to

bring me about to the inversion pattern

now for those of you are not familiar

with my work this will be quite amazing

because this is really the model at the

end of the day as to why it is that it

relates back to me as a software

engineer

I saw early on that this looked like a

network but these different things talk

to each other and that’s part of why I

was happy to put that play on just now

was because you can’t look at the lipid

system in a static manner you have to

look at it in a dynamic manner and once

you do and particularly the more you can

kind of understand networks and software

engineering in my opinion the more you

can get why it can be the way that does

and how well it can function so about I

want to say two and a half years ago I

was at low-carb ville and I brought

these eight data points

that was back when I had only eight

blood tests and I took them over three

months and as you could probably see by

that dotted orange line it seems to

reflect what’s going on above it in that

sort of solid blue line that dotted

orange line is a three-day average of my

dietary fat that solid blue line that’s

my LDL cholesterol so I took that to

low-carb Bale and I stocked all of the

different doctors there the different

researchers and so forth but I actually

happen to have a great conversation with

Ivor Cummins as it happens to be the one

other major engineer there and sure

enough I said you know what I’m gonna do

this I once I get home

because this was taken over three months

and it was about every like 13 14 days

I’m gonna actually do one full week

where I actually eat to a meal plan like

you see here so that I can induce a

curve to see if the LDL cholesterol will

even follow it when I’m doing it one day

after the next actually was going into

the phlebotomist getting my blood drawn

every single day so what happened that

happen sure enough we see the reflection

shown and then of course for my next one

I said well heck what if I just go gin

the fat what if I have tons and tons of

it well we then see the lowest LDL see

that I got since I started since then

you can see with 29 data points the very

beginning of my research what is clearly

what I would call the inversion pattern

and I’m gonna flip the axes on the left

side flip it so that you can actually

see how well it retrofits when you can

see the inversion together

unquestionably one of the most amazing

things that I’ve ever seen and it’s

amazing to me even more so that I’m

actually just looking at nutrition

labels coming to the macros and from the

macros ultimately being able to predict

accurately what the cholesterol levels

will be in my blood now for those of you

who are actually rendered the statistics

mumbo-jumbo the Pearson and the

regression those are amazing scores

and this is what I call the inversion

pattern the dietary fat inversion for

LDL seen it’s really quite simple I’m

right now recording this on a Saturday

so if I were to have taken my blood this

morning I would look backwards three

days the Friday yesterday and the

Thursday before that and then the

Wednesday before that and from those

three days I feel that I can make it

fairly strong guess as to what my

resulting LDL cholesterol would be now

how is it that I can get to that well

I’m going to explain the model to you

and I’m going to warn you this may be

one of the more technical areas but for

the mumbo-jumbo slides don’t worry I’m

gonna slow down and walk you through it

now this is one of those slides the

truth is this is what you hear about all

the time in the ketogenic community and

even outside the ketogenic community

that carbs and protein can be converted

to glucose okay that’s great

you also hear all the time about how fat

can be converted to ketones and that’s

true but here’s the thing you don’t

often hear about it you don’t often hear

about how fat can be delivered directly

to cells until just a moment ago with

our little play showing how they can get

transported in these boats

so these are the other pathways by which

fatty acids can come directly to your

cells but I want to focus on one

particular one I want to focus on the

one that includes that word I want you

to remember

there’s any word I want you to remember

past this it’s triglycerides try as in

three fatty acids three fatty acids

they’re bundled up and they are

basically the stored form of fat and

they’re loaded onto these boats that

your body makes and then sends around

your bloodstream and I’m going to go

off-script for just a sec does anyone

know about what measurement just what

total quantity of LDL particles you have

in your blood stream right now is anyone

want to guess no millions I mean you

think millions how many think trillions

obviously it’s a trick question it’s

millions of trillions it’s known as a

quintillion and it’s a one followed by

18 zeros your body makes these in large

quantities every single week it actually

will synthesize and then reabsorb these

at very high quantities so it’s very

keen to be sure that it delivers these

triglycerides and ultimately then

remodel back to LDL particles so putting

it pretty simply if you were to think of

a boat as a lipoprotein like this cruise

ship what are the passengers passengers

are triglycerides it’s right okay so

what’s the cholesterol on this

cholesterol is the life rafts what is

the purpose of a cruise ship the cruise

ships purpose is actually to mainly move

around the passengers the cruise ships

purpose is not mainly to move around the

life rafts however you wouldn’t get on a

cruise ship that didn’t have life rafts

so you do still want the life rafts it’s

still very relevant and you’ll see why a

little bit more later so this is where

I’m gonna kind of break it out into a

little bit of a diagram and what’s neat

is because of the play beforehand and

everything else we’re helping to kind of

set you up a little bit more

so now let’s define what is an Apple

lipoprotein okay so it’s an additional

protein that binds to the lipid so you

remember these little boats called the

lipoprotein there’s five different ones

that have different ratios of protein

cholesterol triglycerides they’re

carrying vitamin E as the antioxidant so

the Apple lipoprotein is basically the

captain of this ship that’s directing

what’s occurring and we also have

phospholipids which is another type of

lipid that is used in making cellular

membranes so now different

apolipoproteins do different jobs and

they have different names okay their

name simply ABCDE h j l m and they have

also subclasses of names so a would have

a subclass of different names B could

have a subclass so LD L uses Apple B HDL

uses Apple a and IDL uses Apple II so

you can see that these things right here

have different effects for each one of

these so what actually do they do well

they have several things that they do so

number one they would activate certain

enzymes to help the conversion of a VLDL

to an IDL to an LDL so basically they’re

they’re making the fat dissolve from an

enzyme called lipase and then I’m

helping this unload so they can convert

to this end product right here they’re

also involved in transporting or

directing the boats to through the

circulation through the limp to the

cells and they’re also involved in a

communication of where they start to

where they’re supposed to end up so very

simply an apple lipoprotein is the

captain of the boat or the ship and

without them these lipoproteins would be

a mindless bag of fat and cholesterol we

talked about the chylomicrons they came

from the small intestine they came from

food you just ate they got loaded up

with those triglycerides a nice big

payload and then they got sent on their

way to then go ahead and provide that to

your tissues as soon as possible and

once they did and they lost their cargo

they then ultimately get

absorbed back at the liver but there’s

also a line that comes from the liver

primarily of triglycerides that came

ultimately from your fat stores from

your body so when you’re fasting you

absolutely are pulling more of those

triglycerides into these vldls to then

move around and they move into something

known as ideals intermediate density

lipoproteins which can also be absorbed

and this is the story of energy delivery

at least in terms of fatty acids direct

delivery so now let’s talk about this

other part of what lipoproteins do

because it’s not just energy delivery

their support you guys have all heard

about HDL the so-called good cholesterol

what they really mean is the cholesterol

found inside these lipoproteins these

boats and these are in fact very good

they’re very good in your system you

want them operating and doing very well

you just like to see your HDL

cholesterol very high well they also

work closely with LDL particles the so

called bad cholesterol but of course

what they mean is the cholesterol found

in low-density lipoproteins the boat now

you notice this is the one line that’s

pulling double-duty

you see chylomicrons they’re pretty much

delivering energy HDL is pretty much in

a support role this is the energy

delivery this is the support only only

the purple line only vldls to ideals to

LDLs have two jobs

the first job being energy delivery the

second job being in its support role and

I showed you a couple of those support

roles for example in being able to clear

pathogens and also neutralizing free

radicals with vitamin E also known as

alpha tocopheryl you don’t need to

remember that just remember the vitamin

E so now you have to say okay now hold

on I’ve heard that high v LDLs and

triglycerides are associated with

disease that’s true if they’re lingering

how do you know if they’re lingering you

know because it comes up in your blood

test so oftentimes when I’m telling

people about triglyceride so you’re

being

fueled by triglycerides they go and

understand Dave I don’t understand

I see that my triglycerides have dropped

well that’s correct because your usage

of triglycerides has gone up you’re now

using your fat at a much higher degree

and therefore there’s less and less

triglycerides per boat and that might

mean that there’s more LDL particles

that started out as vldls that deliver

the fatty acids you following me all

right so now let’s talk about my low

carb cholesterol challenge I’m gonna

keep putting this into my presentations

until it finally gets answered but I’m

gonna say about eight months ago I open

this challenge and I wanted to put it

out to all sorts of different people I

paint a lot of Lokar a lot of

lipid-lowering experts people who are

not necessarily low-carb who say look

you guys are getting overly comforted

when you have high LDL cholesterol just

because you have high HDL cholesterol

and low triglycerides I’m gonna

constantly call this the triad

those three together and I said that

okay great so why don’t we start looking

at the studies that actually examine all

three of these together the high LDL

cholesterol that so-called bad

cholesterol the high HDL cholesterol

it’s so-called good cholesterol the low

triglycerides because from what I’m

seeing doesn’t look as if there is as

much of a problem but I want to see some

conflicting data so I had this up eight

months ago for six months while I had

this up I got no studies they have done

studies from the other direction again

studies that have shown the opposite

including from our friends at Framingham

this actually was about four thousand

different people and what I loved about

this was it also excluded users of

lipid-lowering therapy so you have a

nice fresh batch of people who didn’t

already have cardiovascular disease at

baseline to see what a difference it

would make for them with heart disease

and this is what we saw I’m sorry is a

little bit mumbo jumbo but the o.r above

is called the odds ratio generally you

want that to be as low as possible

people everybody with an LDL cholesterol

higher than 100 so long as they had

low triglycerides in high HDL we’re

doing fantastic well okay maybe this was

including those people who had like say

an LDL of 102 or 103 so fortunately on

the same chart we also have people who

have an LDL above 130 now that’s a lot

higher but guess what it’s the same 0.7

now we’re talking significantly higher

levels of LDL cholesterol it’s still so

much better but I actually got another

study this one I liked even more because

in this case they were actually using

men who of course are tend to be a lot

higher risk for hardy vascular disease

around 3,000 of them 53 to 74 and they

divided the group by those who have an

LDL of a hundred and seventy or less a

hundred and seventy or less that’s

extremely high or so we’re told to one

hundred and seventy or more but if you

look the darkened bar on the left side

is HDL cholesterol that is above fifty

seven triglycerides below ninety seven

that’s the tertiary if the line is

almost identical on both sides whether

you had whether you had a high or low

LDL cholesterol you ended up in better

shape regardless so long as your HDL was

high the difference is less than two

thirds and 1% but I really want to call

your attention to even more strikingly

at the top end at the risk level where

your HDL is low and your triglycerides

are high that’s nearly identical

regardless of your LDL so I can’t help

it I keep looking at data like this and

I say low LDL high LDL does it seem to

matter as much as HDL and triglycerides

now through a little more humor on it I

said I had that challenge up for six

months two months ago as of two days

coming I went ahead and put some money

behind it so I actually I actually I put

it out there that I would like to give

three hundred dollars to anybody who can

find me at least one study just

one study that showed those people who

have high HDL and low triglycerides with

high LDL would have a higher rate of

cardiovascular disease and I even made

it not even high I said just above

average and I wanted to use the numbers

that the American Heart Association a

lot of different like heart.org for

example just just just above average and

I’ve yet to see one study and I’ve now

put money behind it I have not spent one

time of that bounty thus far so with

that in mind I’m gonna show you some

very very surprising data that came out

of the most recent experiment that I did

with the weight gain and this experiment

before I start talking about it I want

to emphasize to everybody don’t do this

there are a number of experiments that I

kind of have - okey half knots aid I’m

doing this so that you don’t have to

this experiment in particular some

people get inspired to do experiments

like I’ve done this is not one of them I

actually knew I’d need to induce a state

of hyperinsulinemia to accomplish this

but I had an opportunity scenario you

see I still had some weight left over

from a previous couple of experiments my

capstone in my sugar experiments

you have to read up on my blog to hear

about that I know how crazy that sounds

and I had an upcoming trip with an

understanding wife can I just set the

scene there was one night where I walk

into the bedroom and she’s reading and I

go you know honey had really helped my

research a lot if I could gain about 20

pounds of fat that’s how awesome she is

so you know okay who are the experiment

upsides obviously this was a chance to

observe and compare cholesterol at

higher weight on a standard American

diet and to observe what happens when we

change over to ketogenic diet almost all

of that data will be available on the

blog soon but there was an obvious

experiment downside there is short and

long-term risks

I knew this going in and I made this

clear to my wife and I made this clear

to everybody else which is why I don’t

want anyone else to do this obviously

inducing a high level hyperinsulinemia

is not recommended under any

circumstance just avoid that in general

if there’s anything you take from this

conference it’s that so you can actually

see this in the media that I was doing

it around the time of the experiment you

can see my face gets a lot puffy or my

neck gets puffy or etc and this was the

timeline is fairly straightforward Oh

kind of cuts it off a little bit but you

can see I was a little bit of a ramp up

but it’s mainly through the month of

April that I’m actually gaining this

weight and here’s what I was eating

bread a lot of bread I had a lot of

cheesy bread I had a lot of sandwiches

and I had that’s like a chunky steak

meat pie that I was getting from a place

called pie-faced in Australia and I

actually intentionally avoided a lot of

sugary treats because I just wanted to

see you know what would come up with

just a lot of starchy foods just just in

case you were curious works like a charm

in lots of weight I hadn’t yet gained my

my goal weight of 205 so fortunately I

was moving now into a new phase of the

timeline which is for five days I’d be

doing a controlled standard American

diet experiment by that I mean I’d be

eating to a particular plan what does

that plan look like looks like this at

10 a.m. I’d have a footlong Subway

sandwich at 3 p.m. I would have a medium

pepperoni pizza and then at a p.m. I to

have another footlong Subway sandwich

total calories 4217 hungry do you think

I gain weight

I gained weight that didn’t quite give

me to my 205 but I was I was really

ready to stop it there by the way for

anybody who’s contemplating leaving he

doe going I wonder what it’s like to be

like this I wonder if they’ve really

enjoyed it you really honestly did not

enjoy it I’m gonna say there’s only one

thing I find that I miss when I ever I

do these experiments that take me back

to carbs and I’ll be honest about this

it’s the hand-holding part that you

don’t have to use like knives and forks

as much that’s it that’s all anything

else I feel like I get just fine with

keto so okay I’d then take a huge number

of tests and I want to point just to one

in particular that third one from the

left up there that’s my blood pressure

it reads 140 over 86 I’m telling you my

blood pressure normally is around I want

to say 104 over 71 maybe so I really was

ready to step off this experiment I was

getting quite a bit concern now I then

took a whole bunch of blood tests you

only need to be you don’t need to pay

attention to that but then I finally got

to move to the keto phase which was a

lot more refreshing now I got to have

sausage scrambled eggs and I did have to

keep it somewhat mundane so that I could

control for all the variables so it

otherwise was a lot of cheese and

hard-boiled eggs with some almonds this

was a lot better 2437 calories total

carbs 20 and this is effectively what

the controlled phase moving into the

other control phase of the key to look

like so I was literally eating the same

thing in about the same way every single

day and as I like to joke it’s kind of

like Groundhog Day I like when the

audience laughs that because I don’t

feel as old when I say that and so now

if we look at my triglycerides versus

the way my triglycerides in the blood

versus the way we can’t really tell a

lot and that’s because this isn’t a

relative comparison but what if I take

my relative or if I take my weight and

actually do a relative comparison so

that we can see what’s happening between

that five-pound Delta well we see that

it looks like this striking my

triglycerides were much higher during

the standard American diet started

dropping as I started dropping weight

but here

the kicker how many of you guys have

heard show of hands how many guys have

heard that your LDL cholesterol can go

up as you’re losing weight well I’ve

been hearing this for years and as the

cholesterol guy I really wanted to know

and now this was my one chance going

from a standard American diet to keto

and losing weight at the same time I

finally got to find out and this is what

that looks like

my LDL cholesterol had started at a much

lower level at 133 which I’m sure my

doctor would have been a lot happier

with and then as I started losing the

weight it jumped up to 228 that’s a

change of over a hundred milligrams per

deciliter or close to a hundred

milligrams per deciliter through a delta

of just five pounds of weight loss so

without question from now on whenever

anybody is actively losing weight I say

just don’t even look at your lipids but

don’t even bother with it right this is

what it looks like when we invert the

pattern it’s actually quite striking and

the pure scent is amazing it at point

nine three six okay now I’ve got some

new data you’ll notice this table over

here is now starting to pay attention

they were used to my other stuff so this

is the resistance training experiment

now enough you guys have heard but I was

on a podcast recently otherwise I was

the Peter Atia drive and I had a habit

of doing this I have a habit of

announcing my hypotheses in advance

publicly I by the way I had a friend who

said you shouldn’t do that because

you’re gonna eventually embarrass

yourself I said I thought that actually

was what science was is too you know put

forth your hypothesis before you test

the experiment and he said and by the

way he’s a PhD grad he goes well not

anymore so I’m going to tell you them

this is the mumbo jumbo and then I have

a translation one for the next one so

I’m gonna read this aloud again more

Theory this is me talking to Peter I’m

actually going to be testing intensive

exercise myself in the next series of

experiments that I’m doing there is a

difference between those people who are

doing things like say endurance running

and those who are weightlifting or

resistance training in that I think

there is a greater overall gradient of

reset

Durr mediated endocytosis for muscle

repair and growth don’t worry

translation coming I could be wrong

about that but I’ll be very curious to

see if it turns out to be the case when

I’m doing it myself and here’s the

translation of what I really said I said

I think when you make your muscles sore

they eat LDL particles to repair and

grow I hadn’t yet done this experiment

at the time that I did the podcast so I

was very excited to do it this ended up

being the longest controlled experiment

well before I get started let me tell

you how I thought of that well you see

this is a cell membrane and a cell

membrane is made up of two things

especially phospholipids it’s a kind of

lipid and cholesterol that’s what that

little orange guy is there right what’s

a low-density lipoprotein made up of

it’s made up of phospholipids and you

get one guess Wester all okay so why is

there this process that cells have halt

that long word I used before receptor

mediated endocytosis basically the

engulfing of a lipoprotein why do they

have that well i had speculated for some

time that that’s because it’s for raw

material certainly they would say cells

have enough on hand to be able to repair

and synthesize their own cholesterol for

the most part I think that they’re right

but what if the man climbs if you’re

stuck in your home you may have enough

in your garage to be able to do repairs

to your drywall what if you don’t have

enough wouldn’t it be great if Home

Depot was driving by your house every

five minutes saying aide you need

anything doing anything so my theory was

very simple I believed that if I could

control for every other thing that there

was that if I did some intensive

exercise I would see a drop in my LDL

cholesterol because there’d be a drop in

my LDL particle count but in order to do

that I would need to like live my life

the same way day after day after day I

think I could do that okay that was the

plan try to keep everything identical

from one day to the next for 20

days straight so I need to have a big

washout period so I can be sure that I

had a baseline and that was gonna have

the same things the same way every day

but on top of that also control for

exercise I did my usual 2.5 miles of

walking in the afternoon every time and

this is what that looked like no these

are not duplicate pictures this is

literally the pictures they took on

those days and at those times so I

wanted to be sure I control for

everything that I could including even

sleep which I wasn’t always as

successful with and this is what it

looked like this was all of my lipid

numbers taken for my cardio check day

after day up until the first

intervention period then this is what

happened we see not only does it dip

down but actually it starts to come back

up right around the time I happen to be

doing the second intervention phase and

what did that look like that look like

this you can actually see clearly very

well delineated an intervention phase

one we see a drop of around 11% on

intervention phase two where I actually

really hit it I did the weights I went

to the gym and I also got vibration

plates my LDL cholesterol dropped 13%

keeping all other things the same now I

can’t prove that that was entirely into

cytosis I don’t even know for sure how

much of that it was into scientists but

do I believe that that’s still the case

yes what does it take to do that it

takes this takes being able to isolate

every other variable this was also one

other thing I just wanted to point out

that I thought was fascinating as you

can see on the intervention phase I was

also doing glucose versus ketones the

glucose are in the blue at the top the

glucose actually didn’t change that much

but the key talents sure did he tone

production actually went up quite a bit

or I should say perhaps the overage

would have quite a bit because we can’t

actually see the uptake coming into the

cells I thought that was actually quite

fascinating as you can see it starts to

taper back down toward the end of the

experiment now I told you about the fat

experiment I actually want to come back

to because one of the most powerful

slides I have in any presentation I’m

going to show you now and it’s really

gonna drive home a lot of how I

understand LDL cholesterol and

why it is that I still have the state of

uncertainty that I do as far as its risk

so the carotid intima-media thickness

test is a test along the carotid

arteries that are along the side of your

neck and it’s supposed to be effectively

in his used in many studies as a proxy

for a thorough sporadic burden what it’s

trying to do is measure both the

thickness of your intima and your media

together now I have been tracking mine

every six months starting in July of

2016

every six months to my surprise and

appreciation my left carotid artery was

slowly regressing not progressing it

should actually be staying the same or

going up with my age that’s the normal

progression but yet it was actually

going down my right carotid artery

started much higher started at 600 I

want to say around 680 something along

those lines it actually dropped about a

hundred and fifty nanometers while I was

on this ketogenic diet but you remember

I then after we go through all of this I

then go ahead and have the standard

American diet experiment I take my C IMT

toward the end of that standard American

diet experiment and I’ll say I was

speculating there was a chance that

might move north right well sure enough

the left carotid artery jumped up higher

than it had ever been before the right

likewise in fact if you add that last

line you can see just what a pronounced

difference it is following four weeks of

a standard American experiment standard

American diet experiment I really have

to say for any of you guys who right now

are thinking you know what I think I’m

gonna take a break from keto for the

holidays

I want this burned into your head now

obviously I can be somewhat jovial about

it because I am banking on the

regression restarting again and if in

fact that turns out to be true that’ll

be some pretty powerful data there’s me

making another public hypothesis about

my data we’ll see how that turns out now

this went from the lowest ever on both

sides both sides not one side to the

highest ever on both sides showing just

how much of a difference it makes but

this is the part that’s going to bring

it home you see I already read in the

literature several times one of the

contributing factors not just to a

thorough score attic plaque but in

particular to the carotid intima-media

thickness is as you can see highlighted

a high lipoprotein levels high

lipoprotein levels yet look closely if

we add this last column on ldlc and LDL

P I was averaging 200 LDL 200 milligrams

per deciliter of LDL 200 or more

throughout this period of time and my

LDL particle count was 2,000 or more

both considered well into the 90th

percentile of risk at those levels my

left and right carotid arteries were

regressing so what happened to my LDL

see in my LDL P I’ll give you a hint

when I did the standard American diet as

I hypothesized would happen my LDL see

dropped to what it was before I started

keto how much did it drop dropped to 130

my LDL particle was what would be

considered a much more attractive 1130

so if you were looking at this chart

alone and you were saying hey what’s the

best thing that I could do to help

regress the thickness of my intima you

would come to the conclusion the thing I

was doing in the first four rows makes

more sense than the thing I did in the

last row that’s why this data is so

powerful even though it’s only ten data

points so far I want to do one big thank

you to my patrons I want to emphasize

something to all of you I take no money

from any corporate entity in order to

maintain the integrity of my data and so

I’m fortunate

to have literally a hundred and sixty

plus people who actually directly

support my patreon which makes this

research possible could you please give

them a round of applause for me

and thank you so much for your time I

really appreciate it I’m really in love

in this conference thank you so much

you